Description

Tetrakis[(S)-(+)-[(1S)-1-(4-Bromophenyl)-2,2-Diphenylcyclopropanecarboxylato]Dirhodium(II) Rh2(S-Btpcp)4 is a highly specialized chiral dirhodium(II) carboxylate catalyst, distinguished by its unique cyclopropane-based bridging ligand framework. This compound matters for its exceptional ability to facilitate highly enantioselective C-H functionalization, cyclopropanation, and other carbenoid transfer reactions with superior stereocontrol. It is an indispensable tool for pharmaceutical R&D and fine chemical synthesis, where precise stereochemistry is critical for developing active pharmaceutical ingredients (APIs) and advanced intermediates. The product, CAS NO 1345974-63-1, is engineered for researchers and process chemists demanding high-performance, asymmetric catalysts.

Application

• Asymmetric C-H Amination and Insertion Reactions: Enables the stereoselective formation of C-N and C-C bonds for complex heterocycle synthesis.
• Enantioselective Cyclopropanation: A key catalyst for the synthesis of chiral cyclopropane units, valuable scaffolds in medicinal chemistry.
• Pharmaceutical Intermediate Synthesis: Critical for the asymmetric construction of stereogenic centers in the development of novel APIs and drug candidates.
• Fine Chemical and Specialty Chemical Production: Used in the pilot and commercial-scale manufacture of high-value, optically pure compounds.
• Methodology Development in Academic and Industrial Research: Serves as a benchmark catalyst for developing new enantioselective transformations.
• Synthesis of Natural Products and Fragrances: Facilitates the construction of complex molecular architectures with defined chirality.

Basic Information

Product Name	Tetrakis[(S)-(+)-[(1S)-1-(4-Bromophenyl)-2,2-Diphenylcyclopropanecarboxylato]Dirhodium(II)
CAS No.	1345974-63-1
Molecular Formula	C100H68Br4O8Rh2
Molecular Weight	~1860.6 g/mol
Synonyms	Rh2(S-Btpcp)4; Dirhodium(II) tetrakis[(S)-1-(4-bromophenyl)-2,2-diphenylcyclopropanecarboxylate]; (S)-BTFCP Dirhodium Catalyst; Rh2(S-BTPCP)4; Dirhodium(II) (S)-BTPCP complex; Chiral Dirhodium Carboxylate Catalyst; Rh2(S-p-BrC6H4-DPCP)4; Asymmetric Dirhodium Catalyst
EINECS	Contact for details

Quality Control

Every batch of our chiral dirhodium catalysts is produced and analyzed under strict quality control protocols to ensure exceptional purity and catalytic performance. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as enantiomeric excess (ee) of the ligand, Rh content, and purity by HPLC. Our manufacturing aligns with cGMP principles for materials intended for pharmaceutical research, ensuring traceability and consistency. Specifications are tailored to meet the rigorous demands of asymmetric synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere when appropriate to maintain long-term stability and catalytic activity. Keep container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	Dark green to purple crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Rhodium Content	10.5 - 11.5 %
Specific Rotation [α]D20	Contact for details
Solubility	Soluble in chlorinated and aromatic solvents
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.