Description

3'-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-[1,1'-Biphenyl]-3-Carbonitrile is a high-value boronic ester derivative, a key intermediate in modern synthetic chemistry. Its primary value lies in its role as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where precise molecular assembly is critical for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing biphenyl or substituted aromatic scaffolds.
• Agrochemical Synthesis: Used to construct complex molecules for novel herbicides, fungicides, and insecticides, leveraging the Suzuki coupling for efficient carbon-carbon bond formation.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as those used in OLEDs (Organic Light-Emitting Diodes) and semiconductors.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and labeled compounds for biochemical and diagnostic research applications.
• Academic & Industrial R&D: A fundamental reagent for method development and exploratory synthesis in organic chemistry laboratories worldwide.

Basic Information

Product Name	3'-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-[1,1'-Biphenyl]-3-Carbonitrile
CAS No.	1345508-91-9
Molecular Formula	C20H22BNO2
Molecular Weight	319.21 g/mol
Synonyms	[1,1'-Biphenyl]-3-carbonitrile, 3'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 3'-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1'-biphenyl]-3-carbonitrile; 3-Cyano-3'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)biphenyl; 3'-Bpin-[1,1'-biphenyl]-3-carbonitrile; (3'-Cyano-[1,1'-biphenyl]-3-yl)boronic acid pinacol ester; 3-(3-Cyanophenyl)phenylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 3'-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-[1,1'-Biphenyl]-3-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.