Description

1-(2,2,2-Trifluoroethyl)Azetidin-3-Ol is a high-value azetidine derivative, a key building block in modern pharmaceutical and agrochemical research. Its unique structure, featuring a trifluoroethyl group, is critical for modulating the physicochemical properties and biological activity of target molecules. This compound is essential for medicinal chemists and process development scientists working in drug discovery, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A versatile synthon for the development of novel drug candidates, especially in central nervous system (CNS) and metabolic disease research.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group enhances lipophilicity and stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced materials with unique surface properties.
• Fluorine Chemistry Building Block: A critical reagent for introducing the trifluoroethyl motif into complex organic frameworks, a common strategy in bioisostere design.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	1-(2,2,2-Trifluoroethyl)Azetidin-3-Ol
CAS No.	1344365-71-4
Molecular Formula	C5H8F3NO
Molecular Weight	155.12 g/mol
Synonyms	3-Hydroxy-1-(2,2,2-trifluoroethyl)azetidine; 1-(2,2,2-Trifluoroethyl)-3-hydroxyazetidine; 1-(Trifluoroethyl)azetidin-3-ol; Azetidin-3-ol, 1-(2,2,2-trifluoroethyl)-; 3-Azetidinol, 1-(2,2,2-trifluoroethyl)-
EINECS	Contact for details

Quality Control

Our 1-(2,2,2-Trifluoroethyl)Azetidin-3-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can be aligned with cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.