Description

2,2,2-Trifluoro-1-(Tetrahydro-2H-Pyran-3-Yl)Ethanol is a high-value fluorinated chiral building block featuring a trifluoroethanol moiety linked to a tetrahydropyran ring. This unique molecular architecture makes it a critical intermediate for the synthesis of advanced pharmaceuticals and agrochemicals, where the introduction of fluorine atoms can dramatically alter a compound's metabolic stability, lipophilicity, and bioavailability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical industry for constructing complex active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel drug candidates, particularly in antiviral, anti-inflammatory, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms enhance biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated polymers or liquid crystals with unique electronic and surface properties.
• Chemical Biology Probes: Useful for incorporating fluorine tags into molecules for studies using techniques like 19F NMR spectroscopy.

Basic Information

Product Name	2,2,2-Trifluoro-1-(Tetrahydro-2H-Pyran-3-Yl)Ethanol
CAS No.	1342709-61-8
Molecular Formula	C7H11F3O2
Molecular Weight	184.16 g/mol
Synonyms	3-(2,2,2-Trifluoro-1-hydroxyethyl)tetrahydro-2H-pyran; 2,2,2-Trifluoro-1-(tetrahydro-2H-pyran-3-yl)ethan-1-ol; 1-(Oxan-3-yl)-2,2,2-trifluoroethanol; 2,2,2-Trifluoro-1-(3-tetrahydropyranyl)ethanol; TFTHP Ethanol; CAS 1342709-61-8
EINECS	Contact for details

Quality Control

Every batch of 2,2,2-Trifluoro-1-(Tetrahydro-2H-Pyran-3-Yl)Ethanol is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by validated methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its chemical nature, keep away from strong bases and incompatible materials. For long-term storage, consider using an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Chiral Purity (Chiral HPLC)	Contact for details
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.