Description

n-Fmoc-n-(2-Methoxyethyl)-Glycine CAS NO 1341969-00-3 is a specialized, non-proteinogenic amino acid derivative designed for advanced peptide synthesis. This compound is engineered to introduce a flexible, hydrophilic (2-methoxyethyl) side chain into peptide backbones, which is critical for modulating solubility, conformation, and biological activity. It is an essential building block for researchers and manufacturers in pharmaceutical development, particularly for creating peptide-based therapeutics, diagnostic agents, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc-strategy, enabling the controlled assembly of complex peptides.
• Peptidomimetic Drug Design: Used to incorporate structural modifications that enhance metabolic stability, bioavailability, and target specificity of therapeutic peptides.
• Bioconjugation and Linker Chemistry: Serves as a versatile spacer or linker molecule for attaching payloads (e.g., drugs, dyes) to peptides, proteins, or other biomolecules.
• Chemical Biology Research: Employed in the synthesis of custom peptides for studying protein-protein interactions, enzyme mechanisms, and cellular signaling pathways.
• Material Science: Can be used to create peptide-functionalized surfaces, hydrogels, and other biomaterials with tailored properties.

Basic Information

Product Name	n-Fmoc-n-(2-Methoxyethyl)-Glycine
CAS No.	1341969-00-3
Molecular Formula	C₂₁H₂₃NO₆
Molecular Weight	385.41 g/mol
Synonyms	Fmoc-N-(2-Methoxyethyl)glycine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-(2-methoxyethyl)glycine; (2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(2-methoxyethyl)amino)acetic acid; Fmoc-N(MeOEt)-Gly-OH; N-Fmoc-N-(2-methoxyethyl)aminoacetic acid; N-(2-Methoxyethyl)-N-(9-fluorenylmethoxycarbonyl)glycine; Fmoc-N-(β-methoxyethyl)glycine
EINECS	Contact for details

Quality Control

Our n-Fmoc-n-(2-Methoxyethyl)-Glycine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive research and cGMP applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider desiccant and under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.