Description

1-(4-Chloro-2-Fluorophenyl)-2-Methylpropan-1-One is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both chloro and fluoro substituents on the phenyl ring, makes it a versatile precursor for creating complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring halogenated aromatic motifs for bioactivity or metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atom can enhance lipophilicity and target binding.
• Material Science Research: Serves as a monomer or precursor in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: Employed in method development, catalysis studies, and as a standard in analytical chemistry for halogenated compound analysis.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses producing bespoke fine chemicals for client-specific projects.

Basic Information

Product Name	1-(4-Chloro-2-Fluorophenyl)-2-Methylpropan-1-One
CAS No.	1341892-32-7
Molecular Formula	C10H10ClFO
Molecular Weight	200.64 g/mol
Synonyms	4'-Chloro-2'-fluoro-2-methylpropiophenone; 2-Methyl-1-(4-chloro-2-fluorophenyl)propan-1-one; 1-(4-Chloro-2-fluorophenyl)-2-methyl-1-propanone; p-Chloro-o-fluoroisobutyrophenone; Isobutyryl-4-chloro-2-fluorobenzene; α,α-Dimethyl-4-chloro-2-fluorobenzeneacetyl chloride (precursor related); 4-Chloro-2-fluorophenyl isopropyl ketone
EINECS	Contact for details

Quality Control

Our production of 1-(4-Chloro-2-Fluorophenyl)-2-Methylpropan-1-One adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, and our quality systems support compliance with cGMP and ISO standards for research and commercial-scale applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.