Description

2-Amino-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Benzenemethanol is a high-value, multi-functional boronic ester derivative that serves as a critical building block in modern synthetic chemistry. This compound matters because it combines a reactive boronate ester group with both amino and benzylic alcohol functionalities, enabling its use in complex cross-coupling reactions and as a precursor for advanced materials. Pharmaceutical, agrochemical, and material science R&D teams need this chemical for developing new active ingredients, ligands, and functional polymers.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used to construct complex molecular scaffolds for next-generation herbicides, fungicides, and plant growth regulators.
• Material Science & OLED Development: Serves as a building block for creating organic light-emitting diode (OLED) materials and advanced polymeric matrices.
• Ligand & Catalyst Preparation: The amino and alcohol groups allow for chelation and modification, making it useful for designing novel catalysts and chiral ligands.
• Chemical Biology & Proteomics: Employed in the synthesis of activity-based probes and bioconjugation reagents for target identification and protein labeling.
• Academic & Industrial R&D: A versatile reagent for exploring new synthetic methodologies and constructing complex boronic acid-containing molecules.

Basic Information

Product Name	2-Amino-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Benzenemethanol
CAS No.	1339927-45-5
Molecular Formula	C₁₃H₂₀BNO₃
Molecular Weight	249.12 g/mol
Synonyms	2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl alcohol; (2-Amino-5-(hydroxymethyl)phenyl)boronic acid pinacol ester; 5-(Aminomethyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (tautomer); Benzenemethanol, 2-amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; Pinacol [2-amino-5-(hydroxymethyl)phenyl]boronate; B-(2-Amino-5-(hydroxymethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2-Amino-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Benzenemethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and chemical identity. Certificates of Analysis (COA) detailing purity, impurity profile, and physical characteristics are available upon request. We support compliance with REACH, TSCA, and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.