Description

1-Butanone, 1-[3-(Trifluoromethoxy)Phenyl]- is a specialized fluorinated aromatic ketone building block, identified by CAS NO 1339254-57-7. This compound is valued for its unique molecular architecture, which combines a trifluoromethoxy-substituted phenyl ring with a butanone moiety, offering distinct electronic and steric properties for advanced synthesis. It is a critical intermediate for researchers and manufacturers in the pharmaceutical and agrochemical sectors, where the introduction of fluorine-containing groups is essential for modulating the bioactivity, metabolic stability, and physicochemical properties of target molecules.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for CNS drugs and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances lipophilicity and biological activity.
• Liquid Crystal & OLED Materials: Acts as a precursor in the synthesis of fluorinated organic electronic materials for displays and lighting applications.
• Advanced Polymer Chemistry: Employed as a monomer or modifier to create specialty polymers with enhanced chemical resistance and thermal stability.
• Organic Synthesis & Catalysis: A versatile building block in academic and industrial R&D for constructing complex molecules via reactions like Friedel-Crafts acylation or nucleophilic addition.
• Fluorine Chemistry Research: Essential for studying structure-activity relationships (SAR) in medicinal chemistry and material science due to its specific fluorine substitution pattern.

Basic Information

Product Name	1-Butanone, 1-[3-(Trifluoromethoxy)Phenyl]-
CAS No.	1339254-57-7
Molecular Formula	C11H11F3O2
Molecular Weight	232.20 g/mol
Synonyms	1-[3-(Trifluoromethoxy)phenyl]butan-1-one; 3'-Trifluoromethoxybutyrophenone; 3-(Trifluoromethoxy)butyrophenone; 1-Butanone, 1-(3-trifluoromethoxyphenyl)-; 3-Trifluoromethoxybutyrophenone; Butyrophenone, 3'-trifluoromethoxy-; 1-(3-Trifluoromethoxyphenyl)-1-butanone
EINECS	Contact for details

Quality Control

Our production of 1-Butanone, 1-[3-(Trifluoromethoxy)Phenyl]- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to confirm identity, potency, and impurity profiles. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is sensitive to strong alkalis and fluorides; keep away from incompatible materials. For long-term storage, consider using an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.