Description

Isoquinoline, 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-purity boronic ester derivative of isoquinoline, serving as a critical building block in modern synthetic chemistry. Its value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of drug candidates, especially those containing the isoquinoline pharmacophore for neurological, anti-cancer, or anti-infective applications.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides by introducing the functionalized isoquinoline moiety into target molecules.
• Material Science Research: Employed in the development of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its conjugated system.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.
• Chemical Biology Probes: Utilized to create tagged molecules for studying biological processes and protein interactions.
• Academic & R&D: A valuable reagent for methodological development and exploring new synthetic routes in academic and industrial research laboratories.

Basic Information

Product Name	Isoquinoline, 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	1338914-81-0
Molecular Formula	C₁₇H₂₂BNO₂
Molecular Weight	283.18 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline; Isoquinolin-5-ylboronic acid pinacol ester; 5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline; 5-Isoquinolineboronic acid pinacol ester; 5-Boronylisoquinoline pinacol ester; Pinacol 5-isoquinolineboronate; CAS 1338914-81-0
EINECS	Contact for details

Quality Control

Our Isoquinoline, 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive coupling reactions. We employ advanced analytical techniques including NMR, HPLC, and GC-MS for comprehensive characterization. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is light-sensitive (store away from light). Keep the container tightly sealed under an inert atmosphere to minimize exposure to moisture and oxygen, which can affect stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0% (Area %)
Purity (GC)	≥96.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.