Description

3-p-Tolyl-Isothiazole-5-Carboxylic Acid is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its versatile isothiazole-carboxylic acid scaffold, which serves as a critical precursor for the development of novel pharmacologically active compounds and functional materials. This intermediate is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting novel therapeutic agents.
• Agrochemical Synthesis: Used as a building block in the creation of advanced pesticides, herbicides, and fungicides with potentially improved efficacy and selectivity.
• Ligand and Catalyst Development: The carboxylic acid and heterocyclic nitrogen atoms make it a suitable precursor for designing novel ligands in coordination chemistry and catalysis.
• Material Science Research: Employed in the synthesis of specialized polymers, dyes, or organic electronic materials due to its conjugated isothiazole system.
• Chemical Biology Probes: Useful for synthesizing molecular probes and tags for studying biological processes and target engagement.
• Custom Synthesis and Contract Manufacturing: Serves as a starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	3-p-Tolyl-Isothiazole-5-Carboxylic Acid
CAS No.	1338682-63-5
Molecular Formula	C11H9NO2S
Molecular Weight	219.26 g/mol
Synonyms	3-(4-Methylphenyl)-1,2-thiazole-5-carboxylic acid; 3-(p-Tolyl)-1,2-thiazole-5-carboxylic acid; 5-Carboxy-3-(4-methylphenyl)isothiazole; 3-(4-Methylphenyl)isothiazole-5-carboxylic acid; 3-(4-Tolyl)isothiazole-5-carboxylic acid; 3-p-Tolylisothiazole-5-carboxylic acid
EINECS	Contact for details

Quality Control

Our 3-p-Tolyl-Isothiazole-5-Carboxylic Acid is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support development from milligram to kilogram scale with custom synthesis and purity grade options available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.