Description

tert-Butyl 2,3-Dihydro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Inden-2-Ylcarbamate is a high-purity, advanced pharmaceutical intermediate featuring a protected amine and a versatile boronic ester functional group. This compound is critical for enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are fundamental to modern medicinal chemistry. It is primarily utilized by research institutions and pharmaceutical companies in the development of novel active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Suzuki-Miyaura Cross-Coupling: The boronic ester moiety enables efficient carbon-carbon bond formation for constructing complex molecular architectures.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for new therapeutic targets.
• Organic Synthesis: Serves as a versatile intermediate for constructing indane and related polycyclic frameworks in academic and industrial R&D.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Ligand and Catalyst Synthesis: Potential precursor for creating novel ligands and organometallic catalysts.

Basic Information

Item	Details
Product Name	tert-Butyl 2,3-Dihydro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Inden-2-Ylcarbamate
CAS No.	1338547-17-3
Molecular Formula	C20H30BNO4
Molecular Weight	359.27 g/mol
Synonyms	2-[[(1,1-Dimethylethoxy)carbonyl]amino]-2,3-dihydro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indene; 2,3-Dihydro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-inden-2-amine, N-BOC derivative; tert-Butyl N-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-inden-2-yl]carbamate; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-inden-2-yl carbamic acid tert-butyl ester; BOC-protected 5-pinacol boronate indane-2-amine
EINECS	Contact for details

Quality Control

Our tert-Butyl 2,3-Dihydro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Inden-2-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive nature. Allow the container to reach room temperature before opening to minimize condensation and hydrolysis of the boronic ester.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0% (by NMR)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.