Description

tert-Butyl 3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperidine-1-Carboxylate is a high-value, protected boronic ester derivative designed for advanced organic synthesis. This compound matters as a critical building block in modern medicinal chemistry, enabling the efficient construction of complex molecules through reliable cross-coupling reactions. Pharmaceutical R&D and agrochemical manufacturers need this intermediate for the development of novel active ingredients, where its piperidine and pinacol boronate functionalities offer precise structural control.

Application

• Pharmaceutical Intermediate: Key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in CNS and oncology research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides requiring specific piperidine-based architectures.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers and organic electronic materials.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and molecular probes for target identification and validation studies.
• Library Synthesis for High-Throughput Screening: A versatile building block for generating diverse compound libraries in early-stage drug discovery.
• Process Chemistry Development: Used in route scouting and optimization for the scalable production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	tert-Butyl 3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperidine-1-Carboxylate
CAS No.	1338544-06-1
Molecular Formula	C22H34BNO4
Molecular Weight	387.32 g/mol
Synonyms	1-Boc-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine; tert-Butyl 3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperidine-1-carboxylate; 3-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylic acid tert-butyl ester; 1-N-Boc-3-(4-boronophenyl)piperidine pinacol ester; BOC-3-(4-Bpin-phenyl)piperidine; 1338544-06-1; 3-(4-Bpin-phenyl)-1-Boc-piperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperidine-1-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All batches are characterized by NMR (1H, 13C, 11B), HPLC, and mass spectrometry to confirm identity and purity. Comprehensive Certificates of Analysis (COA) detailing purity, residual solvents, and specific impurities are provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.