Description

1,3,2-Dioxaborolane, 2-[2-Chloro-4-[(Methylsulfonyl)Methyl]Phenyl]-4,4,5,5-Tetramethyl- is a high-value, organoboron building block used in advanced synthetic chemistry. This compound matters for its role as a key intermediate in cross-coupling reactions, enabling the efficient construction of complex molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing biaryl and heterobiaryl scaffolds found in drug candidates.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides requiring specific phenyl-boronate derivatives.
• Material Science Research: Serves as a monomer or functionalization agent in the development of organic electronic materials, such as polymers for OLEDs.
• Chemical Biology & Probe Development: Employed in the synthesis of chemical probes and bioconjugation reagents due to its reactive boronate ester group.
• Process Chemistry & Scale-Up: Suitable for optimization and kilogram-scale production of target molecules in pilot plants.
• Academic Research: A valuable reagent for methodology development and exploring new catalytic transformations in university and institutional labs.

Basic Information

Product Name	1,3,2-Dioxaborolane, 2-[2-Chloro-4-[(Methylsulfonyl)Methyl]Phenyl]-4,4,5,5-Tetramethyl-
CAS No.	1338326-90-1
Molecular Formula	C14H20BClO4S
Molecular Weight	342.63 g/mol
Synonyms	2-(2-Chloro-4-((methylsulfonyl)methyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (2-Chloro-4-(methylsulfonylmethyl)phenyl)boronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-[2-chloro-4-(methylsulfonylmethyl)phenyl]-1,3,2-dioxaborolane; 2-Chloro-4-((methylsulfonyl)methyl)benzeneboronic acid pinacol ester; Pinacol [2-chloro-4-(methylsulfonylmethyl)phenyl]boronate; Boronic acid, B-[2-chloro-4-[(methylsulfonyl)methyl]phenyl]-, 1,1-dimethylethyl ester (9CI)
EINECS	Contact for details

Quality Control

Our 1,3,2-Dioxaborolane derivative is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure consistency and compliance with research-grade specifications. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.