Description

2,2,2-Trifluoro-3'-(Trifluoromethylsulfonyl)Acetophenone is a high-value, multi-fluorinated organic building block characterized by its unique trifluoromethylsulfonyl (SO2CF3) and trifluoroacetyl (COCF3) functional groups. This compound matters for its role as a key intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its fluorine content imparts desirable properties like enhanced metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of novel drug candidates, particularly in areas requiring fluorinated motifs for improved bioavailability and binding affinity.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides and pesticides, where fluorine atoms enhance biological activity and environmental persistence.
• Ligand and Catalyst Precursor: Serves as a starting material for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of fluorinated polymers, liquid crystals, and electronic materials to modify surface properties and dielectric constants.
• Custom Synthesis and Contract Manufacturing: A valuable building block for custom chemical synthesis services catering to the needs of biotechnology and fine chemical companies.

Basic Information

Product Name	2,2,2-Trifluoro-3'-(Trifluoromethylsulfonyl)Acetophenone
CAS No.	1335013-85-8
Molecular Formula	C9H4F6O3S
Molecular Weight	306.18 g/mol
Synonyms	1-[3-(Trifluoromethylsulfonyl)phenyl]-2,2,2-trifluoroethanone; 3'-(Trifluoromethylsulfonyl)-2,2,2-trifluoroacetophenone; α,α,α-Trifluoro-3'-(trifluoromethylsulfonyl)acetophenone; 2,2,2-Trifluoro-1-[3-[(trifluoromethyl)sulfonyl]phenyl]ethanone; TFSA; Trifluoromethylsulfonyl Acetophenone Derivative
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-3'-(Trifluoromethylsulfonyl)Acetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.