Description

2,2,2-Trifluoro-1-[4-Fluoro-3-(Trifluoromethyl)Phenyl]Ethanone is a high-value fluorinated aromatic ketone building block. This compound is critical for introducing multiple fluorine atoms into complex molecular architectures, significantly altering their physical, chemical, and biological properties. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients, where its unique trifluoromethyl and fluoro-substituted phenyl ring offers enhanced metabolic stability and lipophilicity.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in oncology, CNS, and anti-infective therapeutic areas.
• Agrochemical Active Ingredient Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require fluorinated motifs for improved efficacy and environmental profile.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials where fluorine incorporation enhances thermal stability and optical properties.
• Chemical Biology & Proteomics: Employed as a building block for designing chemical probes and affinity tags that leverage fluorine's unique NMR properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the scale-up and cGMP production of client-specific fluorinated target molecules.

Basic Information

Product Name	2,2,2-Trifluoro-1-[4-Fluoro-3-(Trifluoromethyl)Phenyl]Ethanone
CAS No.	1335013-55-2
Molecular Formula	C9H3F7O
Molecular Weight	260.11 g/mol
Synonyms	1-(4-Fluoro-3-(trifluoromethyl)phenyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(4-fluoro-3-trifluoromethylphenyl)ethanone; 4'-Fluoro-3'-(trifluoromethyl)trifluoroacetophenone; α,α,α-Trifluoro-4'-fluoro-3'-(trifluoromethyl)acetophenone; TFAP-F-CF3 derivative; F3C-C6H3(F)-CO-CF3
EINECS	Contact for details

Quality Control

Every batch of our 2,2,2-Trifluoro-1-[4-Fluoro-3-(Trifluoromethyl)Phenyl]Ethanone is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for advanced synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as characterized by HPLC, GC, NMR, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.