Description

2-Isopropoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-(Trifluoromethyl)Pyridine is a high-value, multi-functional boronic ester derivative, serving as a critical synthetic intermediate in modern organic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially those containing trifluoromethylpyridine motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific pyridine-based structures.
• Material Science Research: Serves as a precursor for creating novel organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura cross-coupling to introduce the substituted pyridine moiety into more complex molecules.
• Chemical Biology & Medicinal Chemistry: A valuable tool for structure-activity relationship (SAR) studies and the discovery of new drug candidates through combinatorial chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to fine chemical companies for the custom synthesis of proprietary compounds for clients across various industries.

Basic Information

Product Name	2-Isopropoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-(Trifluoromethyl)Pyridine
CAS No.	1334607-81-6
Molecular Formula	C15H21BF3NO3
Molecular Weight	331.14 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-isopropoxy-3-(trifluoromethyl)pyridine; 2-Isopropoxy-3-trifluoromethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 3-(Trifluoromethyl)-2-isopropoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; Pinacol 2-Isopropoxy-3-(trifluoromethyl)pyridine-5-boronate; 2-(Isopropoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridine; Pyridine, 2-isopropoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-Isopropoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (¹H, ¹³C, ¹¹B), HPLC, and GC analysis, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Recommended long-term storage temperature is 2-8°C (refrigerated) for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical: 97-99%)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.