Description

Carbonochloridic Acid, [4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methyl Ester is a high-value, specialized organoboron building block that combines a reactive chloroformate group with a protected boronic acid moiety. This compound matters as a critical intermediate for the precise synthesis of complex molecules, enabling efficient cross-coupling reactions and targeted functionalization. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for constructing novel active ingredients, as well as by advanced material scientists developing functional polymers and sensors.

Application

• Pharmaceutical Intermediate: Key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and CNS research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the boronic ester facilitates the introduction of complex aromatic systems.
• Material Science Research: Enables the functionalization of polymers and surfaces with boronic acid groups for applications in sensing and smart materials.
• Chemical Biology Probes: Serves as a precursor for synthesizing activity-based probes and molecular tags used in proteomics and diagnostic assay development.
• Ligand and Catalyst Development: Acts as a versatile synthon for creating novel ligands and organocatalysts used in asymmetric synthesis.
• Academic & Industrial R&D: Essential reagent for method development and exploring new synthetic pathways in organic chemistry laboratories worldwide.

Basic Information

Product Name	Carbonochloridic Acid, [4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methyl Ester
CAS No.	1334019-92-9
Molecular Formula	C14H18BClO4
Molecular Weight	296.55 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl chloroformate; [4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl carbonochloridate; 2-(4-(Chlorocarbonyloxy)methyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol (4-(Chlorocarbonyloxy)methyl)phenyl)boronate; (4-(Chloroformyloxy)methyl)phenyl)boronic acid pinacol ester; Benzyl Chloroformate Boronic Ester; BOC-protected Benzyl Chloroformate Boronate
EINECS	Contact for details

Quality Control

Our production of Carbonochloridic Acid, [4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methyl Ester adheres to stringent quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP and ISO 9001 compliant manufacturing for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.