Description

1-(Phenylsulfonyl)-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole is a high-purity, synthetically valuable boronic ester derivative, serving as a critical building block in modern organic synthesis. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecular architectures. This advanced intermediate is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries, facilitating the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly for constructing biaryl and heterobiaryl scaffolds common in kinase inhibitors and other therapeutic agents.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides by enabling the modular assembly of complex aromatic systems.
• Material Science & OLED Development: Serves as a building block for creating organic semiconductors, light-emitting materials, and advanced polymers with tailored electronic properties.
• Chemical Biology & Probe Synthesis: Employed in the preparation of labeled compounds and molecular probes for studying biological pathways and target engagement.
• Academic & Contract Research: A vital reagent for methodology development and complex molecule synthesis in university and CRO laboratory settings.
• Scale-up Process Chemistry: Suitable for optimization and pilot-scale production runs, supporting the transition from discovery to commercial manufacturing.

Basic Information

Product Name	1-(Phenylsulfonyl)-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole
CAS No.	1333344-24-3
Molecular Formula	C20H22BNO4S
Molecular Weight	383.27 g/mol
Synonyms	6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(phenylsulfonyl)-1H-indole; 1H-Indole, 1-(phenylsulfonyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 1-Benzenesulfonyl-6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-indole; 1-(Phenylsulfonyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indole; 6-Pinacolatoboryl-1-(phenylsulfonyl)indole
EINECS	Contact for details

Quality Control

Our 1-(Phenylsulfonyl)-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep the container tightly sealed in a desiccated environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Assay (NMR)	≥95.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.