Description

Benzyl 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Ylcarbamate is a high-purity, synthetically valuable boronic ester derivative. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in modern organic synthesis, particularly for Suzuki-Miyaura cross-coupling reactions. It is essential for research and development teams in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality precursors for complex molecule construction.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially those containing complex pyridine and biaryl motifs.
• Suzuki-Miyaura Cross-Coupling: Serves as a stable, air-handleable boronate ester reagent for palladium-catalyzed carbon-carbon bond formation to create biaryl structures.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that incorporate heterocyclic boron chemistry.
• Material Science & OLED Development: A building block for creating organic electronic materials, such as ligands for metal-organic frameworks (MOFs) and emissive layers in OLEDs.
• Chemical Biology & Probe Synthesis: Utilized in the design and synthesis of molecular probes and inhibitors for biological target identification and validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-directed synthesis projects requiring specific boronic ester functionalities.

Basic Information

Product Name	Benzyl 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Ylcarbamate
CAS No.	1333319-53-1
Molecular Formula	C20H25BN2O4
Molecular Weight	368.24 g/mol
Synonyms	Benzyl (4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)carbamate; 2-(((Benzyloxy)carbonyl)amino)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; Benzyl N-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridyl]carbamate; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine, N-Cbz derivative; Pinacol ester of (2-(((Benzyloxy)carbonyl)amino)pyridin-4-yl)boronic acid
EINECS	Contact for details

Quality Control

Our Benzyl 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 11B), and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with cGMP and ICH Q7 guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry, well-ventilated place. Keep away from heat, sparks, and open flame. Allow the container to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.