Description

Methyl 2-(Aminomethyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate is a high-value, multi-functional chemical building block that combines a benzoate ester, a primary amine, and a pinacol boronate ester in a single molecule. This unique structure makes it a critical intermediate for the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily utilized by R&D chemists and process development scientists in the life sciences sector for constructing novel active pharmaceutical ingredients (APIs) and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those requiring Suzuki-Miyaura cross-coupling reactions.
• Proteolysis Targeting Chimera (PROTAC) Development: Used to construct linker components that connect E3 ligase ligands to target protein ligands.
• Bioconjugation & Labeling Reagents: The amine and boronate functional groups allow for selective conjugation to biomolecules or fluorescent tags.
• Material Science Research: Serves as a monomer or functionalization agent in the development of advanced polymers and organic electronic materials.
• Agrochemical Synthesis: Employed in the research phase for creating novel herbicides or fungicides with specific targeting properties.
• Chemical Biology Probes: Utilized to create molecular probes for studying enzyme function and protein-protein interactions.

Basic Information

Product Name	Methyl 2-(Aminomethyl)-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate
CAS No.	1333319-47-3
Molecular Formula	C16H24BNO4
Molecular Weight	305.18 g/mol
Synonyms	2-(Aminomethyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid methyl ester; Methyl 3-borono-2-(aminomethyl)benzoate, pinacol ester; 2-(Aminomethyl)-3-(pinacolatoboryl)methyl benzoate; Methyl 2-(aminomethyl)-3-(pinacolatoboryl)benzoate; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(aminomethyl)benzoic acid methyl ester; Boronic acid, B-[2-(aminomethyl)-3-(methoxycarbonyl)phenyl]-, pinacol ester
EINECS	Contact for details

Quality Control

Our Methyl 2-(Aminomethyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our commitment to quality supports your research and development needs with reliable, high-purity materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to ensure long-term stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.