Description

5-Fluoro-6-Benzoxypyridine-3-Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. This compound is valued for its role in facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. It is essential for researchers and manufacturers in pharmaceutical development, agrochemical research, and materials science who require reliable, high-quality boron reagents for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates containing the benzoxypyridine scaffold.
• Agrochemical Research: Used in the discovery and development of novel herbicides, fungicides, and insecticides that require fluorinated heterocyclic components.
• Material Science: Serves as a precursor for creating organic electronic materials, such as ligands for OLEDs and other fluorinated functional polymers.
• Suzuki-Miyaura Cross-Coupling: The pinacol ester group protects the boronic acid, enhancing stability and handling for efficient C-C bond formation under mild conditions.
• Chemical Library Synthesis: Enables the rapid generation of diverse compound libraries for high-throughput screening in drug discovery programs.
• Ligand Synthesis: Used in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	5-Fluoro-6-Benzoxypyridine-3-Boronic Acid Pinacol Ester
CAS No.	1333222-45-9
Molecular Formula	C₁₇H₁₇BFNO₃
Molecular Weight	313.14 g/mol
Synonyms	5-Fluoro-6-benzoxypyridin-3-ylboronic acid pinacol ester; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-fluoro-1,2-benzoxazole; 5-Fluoro-1,2-benzoxazol-3-ylboronic acid pinacol ester; 5-Fluoro-6-benzoxazolyl-3-boronic acid pinacol ester; (5-Fluoro-1,2-benzoxazol-3-yl)boronic acid pinacol ester; 1333222-45-9; BRN 9089625
EINECS	Contact for details

Quality Control

Our 5-Fluoro-6-Benzoxypyridine-3-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment. We adhere to cGMP principles for pharmaceutical intermediates, ensuring traceability and batch-to-batch consistency for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.