Description

trans-Cyclobutane-1,3-Diol is a high-purity, stereochemically defined diol building block of significant interest in advanced organic synthesis. Its rigid, strained cyclobutane ring and specific stereochemistry make it a valuable scaffold for constructing complex molecules with precise three-dimensional architecture. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, chiral ligand synthesis, and materials science.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those requiring constrained, three-dimensional structures to enhance target binding and metabolic stability.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides where the cyclobutane core can impart unique biological activity and selectivity.
• Chiral Auxiliary/Ligand Precursor: Serves as a starting material for the preparation of chiral ligands and catalysts used in asymmetric synthesis to control stereochemistry in chemical reactions.
• Materials Science Research: Investigated as a monomer or cross-linking agent for creating polymers with unique thermal and mechanical properties due to the inherent ring strain of the cyclobutane unit.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tools for studying biological systems and enzyme mechanisms.
• Flavor & Fragrance Chemistry: Potential intermediate for synthesizing complex odorants and flavor compounds with specific stereochemical notes.

Basic Information

Product Name	trans-Cyclobutane-1,3-Diol
CAS No.	1332482-75-3
Molecular Formula	C4H8O2
Molecular Weight	88.11 g/mol
Synonyms	(1R,3S)-Cyclobutane-1,3-diol; (1S,3R)-Cyclobutane-1,3-diol; trans-1,3-Cyclobutanediol; 1,3-Cyclobutanediol, trans-; rac-trans-1,3-Cyclobutanediol; Cyclobutane-1,3-diol, (1R,3S)-rel-; 1,3-Dihydroxycyclobutane
EINECS	Contact for details

Quality Control

Our trans-Cyclobutane-1,3-Diol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing identity, purity, and specific test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de (trans isomer)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.