Description

1-Bromo-3-Methoxy-5-(Trifluoromethoxy)Benzene is a high-value, multi-functional aromatic building block designed for advanced organic synthesis. Its unique structure, featuring bromine, methoxy, and trifluoromethoxy substituents, makes it an essential intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and anti-inflammatory drugs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for advanced electronic materials, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs), due to its aromatic core and halogen substituents.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Stille) to form biaryl structures.
• Ligand & Catalyst Development: Utilized in the design and synthesis of novel ligands and organocatalysts for asymmetric synthesis and other specialized catalytic processes.
• Polymer & Resin Modification: Incorporated into polymer backbones to impart specific properties like flame retardancy, chemical resistance, or altered solubility.

Basic Information

Product Name	1-Bromo-3-Methoxy-5-(Trifluoromethoxy)Benzene
CAS No.	1330750-28-1
Molecular Formula	C8H6BrF3O2
Molecular Weight	271.04 g/mol
Synonyms	3-Bromo-5-methoxy-1-(trifluoromethoxy)benzene; 5-Bromo-1-methoxy-3-(trifluoromethoxy)benzene; 1-Bromo-3-methoxy-5-(trifluoromethoxy)benzene; 3-Methoxy-5-(trifluoromethoxy)bromobenzene; m-Bromo-m'-methoxy-m''-(trifluoromethoxy)benzene; Benzene, 1-bromo-3-methoxy-5-(trifluoromethoxy)-; CAS 1330750-28-1
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-Methoxy-5-(Trifluoromethoxy)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and batch-to-batch consistency suitable for sensitive R&D and scale-up processes. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Standard Grade)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.