Description

5-Thiazole Boronic Acid Mida Ester is a specialized organoboron reagent where the boronic acid functionality is protected as a stable N-methyliminodiacetic acid (MIDA) ester. This advanced synthetic intermediate is crucial for modern cross-coupling chemistry, offering enhanced stability, solubility, and handling characteristics compared to its free boronic acid counterpart. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the efficient, iterative synthesis of complex heterocyclic targets, particularly in Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates containing the thiazole heterocycle, which is prevalent in bioactive molecules.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable, air- and moisture-tolerant coupling partner for the construction of biaryl and heterobiaryl bonds in complex molecule assembly.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that incorporate thiazole-based structures.
• Material Science: Potential precursor for creating organic electronic materials and ligands for catalysis through its functional boronate group.
• Iterative Synthesis: The MIDA boronate protection allows for sequential, orthogonal cross-coupling strategies, enabling the synthesis of complex, polyfunctionalized molecules.
• Chemical Biology & Probe Development: Useful for labeling and modifying biomolecules or creating chemical probes for biological target identification.

Basic Information

Product Name	5-Thiazole Boronic Acid Mida Ester
CAS No.	1329539-52-7
Molecular Formula	C10H13BN2O4S
Molecular Weight	268.10 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole MIDA ester; Thiazol-5-ylboronic acid MIDA ester; 1-Methyl-2,6-dioxo-4-(thiazol-5-yl)-1,3,2λ⁴,6λ⁴-dioxazaborinane; 5-Thiazolylboronic Acid N-Methyliminodiacetic Acid Ester; MIDA Boronate of 5-Thiazoleboronic Acid; 5-Boronothiazole MIDA Ester; CAS 1329539-52-7
EINECS	Contact for details

Quality Control

Every batch of 5-Thiazole Boronic Acid Mida Ester is produced and tested under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and scale-up applications. Our standard quality control includes comprehensive analysis via NMR (¹H, ¹³C, ¹¹B), HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and specification compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) for long-term storage to maintain stability and purity. Keep the container sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.