Description

(trans-3-(p-Tolyl)Oxiran-2-Yl)Boronic Acid Mida Ester is a specialized organoboron building block that combines the stability of an N-methyliminodiacetic acid (MIDA) boronate with the reactivity of an epoxide. This compound is engineered to provide superior shelf stability and controlled reactivity, making it a critical reagent for advanced synthetic methodologies. It is primarily utilized by researchers and process chemists in the pharmaceutical and agrochemical industries for the precise construction of complex molecular architectures, particularly in cross-coupling reactions and medicinal chemistry programs.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Acts as a stable, air- and moisture-tolerant boronic acid surrogate for the synthesis of biaryl and heterobiaryl compounds.
• Medicinal Chemistry & Drug Discovery: Serves as a key intermediate in the synthesis of potential drug candidates, enabling the late-stage functionalization of complex molecules.
• Agrochemical Synthesis: Used in the research and development of novel active ingredients, such as herbicides and fungicides, that require specific stereochemistry.
• Material Science Research: Employed in the creation of organic electronic materials and ligands for catalysis where precise molecular control is essential.
• Peptide and Protein Modification: Facilitates site-specific labeling and conjugation strategies due to its orthogonal reactivity profile.
• Academic Research & Process Development: A valuable tool for developing new synthetic routes and methodologies in organic chemistry laboratories.

Basic Information

Product Name	(trans-3-(p-Tolyl)Oxiran-2-Yl)Boronic Acid Mida Ester
CAS No.	1329422-50-5
Molecular Formula	C14H16BNO5
Molecular Weight	289.09 g/mol
Synonyms	trans-3-(4-Methylphenyl)oxiran-2-ylboronic acid MIDA ester; (trans-3-(4-Methylphenyl)oxirane-2-yl)boronic acid N-methyliminodiacetic acid ester; (trans-3-(p-Tolyl)oxirane-2-yl)boronic acid MIDA ester; (trans-3-(4-Tolyl)oxiran-2-yl)boronic acid MIDA ester; B-(trans-3-(4-Methylphenyl)oxiran-2-yl)-N-methyliminodiacetic acid boronate; p-Tolyl epoxide MIDA boronate; Boronic acid, B-[trans-3-(4-methylphenyl)oxiran-2-yl]-, N-methyliminodiacetate ester
EINECS	Contact for details

Quality Control

Every batch of (trans-3-(p-Tolyl)Oxiran-2-Yl)Boronic Acid Mida Ester is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistent performance for critical research and development applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain long-term stability. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.