Description

(trans-3-Phenyloxiran-2-Yl)Boronic Acid Mida Ester is a high-value, protected boronic acid derivative designed for advanced synthetic applications. Its core value lies in the MIDA (N-methyliminodiacetic acid) ester group, which stabilizes the boronic acid moiety, enabling complex multi-step synthesis and purification protocols that are challenging with standard boronic acids. This compound is essential for researchers and process chemists in pharmaceutical development, particularly for Suzuki-Miyaura cross-coupling reactions in the synthesis of complex drug candidates and bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) via palladium-catalyzed cross-coupling reactions.
• Medicinal Chemistry Research: Used in the discovery and optimization of new drug candidates, especially where air- and moisture-sensitive boronic acids are required.
• Complex Molecule Synthesis: Enables the sequential introduction of multiple boronic acid species in one-pot or multi-step synthesis due to its enhanced stability.
• Ligand and Catalyst Development: Serves as a precursor for creating novel boron-containing ligands or organocatalysts.
• Material Science Research: Potential use in the development of organic electronic materials and polymers through controlled coupling reactions.

Basic Information

Product Name	(trans-3-Phenyloxiran-2-Yl)Boronic Acid Mida Ester
CAS No.	1329422-25-4
Molecular Formula	C₁₃H₁₄BNO₅
Molecular Weight	275.07 g/mol
Synonyms	trans-2-(3-Phenyloxiran-2-yl)-1,3,2-dioxaborolane-4,6-dione, N-methyliminodiacetic ester; (trans-2-Phenyl-2-oxiranyl)boronic acid MIDA ester; (2R,3S)-2-(3-Phenyloxiran-2-yl)-5,5-dimethyl-1,3,2-dioxaborinan-4-one (related stereoisomer); Boronic acid, B-(trans-2-phenyl-2-oxiranyl)-, N-methyliminodiacetic ester; MIDA Boronate Ester of trans-3-Phenylglycidylboronic Acid; B-(trans-2-Phenyloxiran-2-yl)boronic acid MIDA ester.
EINECS	Contact for details

Quality Control

Our (trans-3-Phenyloxiran-2-Yl)Boronic Acid Mida Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research and development. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep container tightly sealed in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.