Description

1-Methyl-4-[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl]Piperidine is a high-value, advanced pharmaceutical intermediate featuring a unique piperidine-pyrazole-boronic ester scaffold. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules through versatile cross-coupling reactions. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients, particularly in kinase inhibitor and CNS drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted small-molecule drugs, especially kinase inhibitors and central nervous system (CNS) agents.
• Suzuki-Miyaura Cross-Coupling Reactions: The protected boronic ester group serves as a stable handle for efficient palladium-catalyzed carbon-carbon bond formation.
• Medicinal Chemistry & Drug Discovery: Used in lead optimization and library synthesis to explore structure-activity relationships (SAR) around the piperidine-pyrazole core.
• Agrochemical Research: Employed in the development of new herbicides and fungicides with novel modes of action.
• Chemical Biology Probes: Utilized to create tool compounds for studying biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of clinical trial materials and niche active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1-Methyl-4-[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl]Piperidine
CAS No.	1323919-64-7
Molecular Formula	C15H26BN3O2
Molecular Weight	291.20 g/mol
Synonyms	1-Methyl-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine; 4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)-1-methylpiperidine; 1-Methyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine; Piperidine, 1-methyl-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]-; 1-Methyl-4-(4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine; CAS 1323919-64-7
EINECS	Contact for details

Quality Control

Our 1-Methyl-4-[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl]Piperidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. For long-term storage, keep the container under an inert atmosphere (e.g., nitrogen or argon) at a recommended temperature of 2-8°C to maintain stability. The compound is moisture-sensitive; keep the container tightly sealed and desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.