Description

2-Fluoro-1-Iodo-4-(Trifluoromethoxy)Benzene is a high-value, multi-functional halogenated aromatic building block. This compound matters for its unique molecular architecture, combining fluorine, iodine, and a trifluoromethoxy group to enable precise structural modifications in advanced synthesis. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in fluorine-containing drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated compounds for electronic display materials and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to construct complex biaryl systems.
• Positron Emission Tomography (PET) Tracer Development: The fluorine-18 analog is of significant interest for radiolabeling and developing diagnostic imaging agents.
• Material Science Research: Employed in creating novel polymers and advanced organic frameworks with specific electronic or surface properties.

Basic Information

Product Name	2-Fluoro-1-Iodo-4-(Trifluoromethoxy)Benzene
CAS No.	1321963-74-9
Molecular Formula	C7H3F4IO
Molecular Weight	305.99 g/mol
Synonyms	1-Fluoro-2-iodo-5-(trifluoromethoxy)benzene; 2-Fluoro-1-iodo-4-(trifluoromethoxy)benzene; 4-(Trifluoromethoxy)-2-fluoroiodobenzene; 1-Iodo-2-fluoro-4-(trifluoromethoxy)benzene; Benzene, 2-fluoro-1-iodo-4-(trifluoromethoxy)-; 2-Fluoro-4-(trifluoromethoxy)iodobenzene; 2-Fluoro-α,α,α-trifluoro-p-iodoanisole
EINECS	Contact for details

Quality Control

Our 2-Fluoro-1-Iodo-4-(Trifluoromethoxy)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency suitable for research and scale-up applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.