Description

4-Acetyl-2-Methylphenylboronic Acid Pinacol Ester is a high-purity, protected boronic acid derivative essential for advanced organic synthesis. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries for developing new active ingredients and functional materials.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of biaryl compounds, a common scaffold in pharmaceuticals and organic electronics.
• Pharmaceutical Intermediate: Used in the research and development of novel active pharmaceutical ingredients (APIs), particularly for creating sterically hindered biaryl structures.
• Agrochemical Synthesis: Employed in the production of advanced herbicides, fungicides, and insecticides that require specific, complex aromatic frameworks.
• Material Science Research: Acts as a monomer or building block for creating organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs).
• Chemical Biology & Proteomics: Utilized in the development of chemical probes and inhibitors that target specific enzymes or biological pathways.
• Scale-up Process Chemistry: The pinacol ester protection enhances stability, making this reagent suitable for multi-step synthesis and larger-scale manufacturing processes.

Basic Information

Product Name	4-Acetyl-2-Methylphenylboronic Acid Pinacol Ester
CAS No.	1321848-43-4
Molecular Formula	C15H21BO3
Molecular Weight	260.14 g/mol
Synonyms	(4-Acetyl-2-methylphenyl)boronic acid pinacol ester; 2-Methyl-4-acetylphenylboronic acid pinacol ester; 1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-methylphenyl)ethan-1-one; 4-Acetyl-o-tolylboronic acid pinacol ester; Pinacol (4-acetyl-2-methylphenyl)boronate; Boronic acid, B-(4-acetyl-2-methylphenyl)-, 1,1-dimethylethyl ester (9CI)
EINECS	Contact for details

Quality Control

Our 4-Acetyl-2-Methylphenylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is analyzed using advanced techniques including NMR, HPLC, and GC to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting compliance in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.