Description

Methyl 2,6-Difluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. Its core value lies in the strategic incorporation of both a protected boronic ester and a methyl ester, enabling efficient cross-coupling reactions and subsequent functional group transformations. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who require precise, high-quality intermediates for developing active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing difluorophenyl and boronic acid ester motifs.
• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronate ester group serves as a crucial coupling partner for forming carbon-carbon bonds with aryl or vinyl halides, a fundamental step in medicinal chemistry.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides that benefit from the introduced fluorine atoms for enhanced biological activity and metabolic stability.
• Material Science Research: Employed as a monomer or precursor in the development of organic electronic materials, such as polymers for OLEDs or semiconductors.
• Chemical Biology & Probe Development: Useful for creating molecular probes and labeled compounds due to the reactivity of the boronate ester for bioconjugation strategies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research laboratories for custom synthesis projects requiring this specific, high-value chemical scaffold.

Basic Information

Item	Details
Product Name	Methyl 2,6-Difluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate
CAS No.	1321613-00-6
Molecular Formula	C14H17BF2O4
Molecular Weight	298.10 g/mol
Synonyms	Methyl 2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate; 2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic Acid Methyl Ester; Methyl 4-Borono-2,6-difluorobenzoate Pinacol Ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,6-difluorobenzoic Acid Methyl Ester; 1321613-00-6; Methyl 2,6-difluoro-4-(pinacolatoboron)benzoate
EINECS	Contact for details

Quality Control

Our Methyl 2,6-Difluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request. We support compliance with REACH and other relevant global regulatory frameworks for our customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged procedures to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.