Description

2-(Trifluoromethyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-6-Methylpyridine is a high-value, multi-functional organoboron building block, specifically a pyridine-substituted pinacol boronic ester. This compound is critical for enabling advanced cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are foundational to modern synthetic chemistry. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures with precision.

Application

• Pharmaceutical Intermediate: A key synthon for constructing active pharmaceutical ingredients (APIs), particularly those containing trifluoromethylpyridine motifs which enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the boronic ester group allows for efficient coupling to create diverse heterocyclic structures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, including ligands for metal-organic frameworks (MOFs) and components for organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura couplings to form carbon-carbon bonds between the pyridine ring and various aryl or heteroaryl halides.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and tags for studying biological systems and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring specific, high-purity boronic esters.

Basic Information

Product Name	2-(Trifluoromethyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-6-Methylpyridine
CAS No.	1321518-03-9
Molecular Formula	C13H17BF3NO2
Molecular Weight	287.09 g/mol
Synonyms	4,4,5,5-Tetramethyl-2-[6-methyl-2-(trifluoromethyl)pyridin-4-yl]-1,3,2-dioxaborolane; 2-(Trifluoromethyl)-6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 6-Methyl-2-(trifluoromethyl)pyridine-4-boronic acid pinacol ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)-6-methylpyridine; 2-(Trifluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-picoline; Pinacol [6-methyl-2-(trifluoromethyl)pyridin-4-yl]boronate
EINECS	Contact for details

Quality Control

Our production of 2-(Trifluoromethyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-6-Methylpyridine adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications and supporting regulatory requirements for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.