Description

5-Hydroxypyrazine-2-Boronic Acid Pinacol Ester is a high-value boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries, particularly in the development of active pharmaceutical ingredients (APIs) and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially those containing pyrazine or complex heterocyclic cores.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boron-containing coupling partner for the formation of carbon-carbon bonds with aryl/heteroaryl halides.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with pyrazine-based structures.
• Ligand & Catalyst Development: Employed in the preparation of specialized ligands for catalysis or as a precursor for functional materials.
• Chemical Biology Probes: Useful for creating tagged molecules or probes for studying biological systems and target engagement.
• Advanced Material Synthesis: A building block for organic electronic materials, such as those used in OLEDs or organic semiconductors.

Basic Information

Product Name	5-Hydroxypyrazine-2-Boronic Acid Pinacol Ester
CAS No.	1320747-35-0
Molecular Formula	C11H15BN2O3
Molecular Weight	234.06 g/mol
Synonyms	5-Hydroxypyrazine-2-boronic acid pinacol ester; 2-(5-Hydroxypyrazin-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-Hydroxy-2-pyrazineboronic acid pinacol ester; 5-Hydroxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazine; Pinacol 5-hydroxypyrazine-2-boronate; 5-Hydroxy-pyrazine-2-boronic acid pinacol ester; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-hydroxypyrazine
EINECS	Contact for details

Quality Control

Our 5-Hydroxypyrazine-2-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems support the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep container tightly sealed in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.