Description

(5-Chloro-2-[(2,2-Dimethylpropoxy)Carbonyl]Phenyl)Boronic Acid CAS NO 1315476-05-1 is a high-purity, synthetically valuable organoboron compound featuring a neopentyl ester-protected carboxylic acid group. This advanced pharmaceutical intermediate is specifically engineered for Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern drug discovery. It is essential for research chemists and process development teams in the pharmaceutical and agrochemical industries seeking to construct complex biaryl scaffolds with high efficiency and selectivity.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing biphenyl or heterobiaryl motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific chlorinated biaryl structures.
• Material Science Research: Employed in the creation of organic electronic materials, ligands for catalysts, and advanced polymers via palladium-catalyzed coupling.
• Chemical Biology & Probe Development: Serves as a versatile handle for bioconjugation and the synthesis of molecular probes for diagnostic and research applications.
• Process Chemistry & Scale-up: Suitable for development from milligram-scale discovery chemistry to kilogram-scale pilot plant production under optimized conditions.

Basic Information

Product Name	(5-Chloro-2-[(2,2-Dimethylpropoxy)Carbonyl]Phenyl)Boronic Acid
CAS No.	1315476-05-1
Molecular Formula	C14H18BClO4
Molecular Weight	296.55 g/mol
Synonyms	5-Chloro-2-[(2,2-dimethylpropoxy)carbonyl]benzeneboronic acid; (5-Chloro-2-(neopentyloxycarbonyl)phenyl)boronic acid; 2-Borono-5-chlorobenzoic acid neopentyl ester; Neopentyl 5-chloro-2-boronobenzoate; (5-Chloro-2-(pivaloyloxymethyl)phenyl)boronic acid (common alias); CAS 1315476-05-1; Boronic acid, B-[5-chloro-2-[[(2,2-dimethylpropoxy)carbonyl]phenyl]- (IUPAC)
EINECS	Contact for details

Quality Control

Our (5-Chloro-2-[(2,2-Dimethylpropoxy)Carbonyl]Phenyl)Boronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for sensitive coupling reactions. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon/nitrogen) for long-term storage to maintain optimal purity and reactivity. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (Boronic Acid)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.