Description

6-Bromo-1-(Toluene-4-Sulfonyl)-1H-Indole-3-Boronic Acid Pinacol Ester is a high-value, multi-functional synthetic intermediate crucial for modern cross-coupling reactions. Its core value proposition lies in enabling the precise construction of complex indole-based molecular architectures, which are foundational scaffolds in numerous active compounds. This advanced building block is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where it facilitates the development of new drug candidates, crop protection agents, and functional organic molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel indole-containing drug candidates targeting various therapeutic areas.
• Agrochemical Research: Used in the discovery and development of new-generation pesticides and herbicides with complex heterocyclic structures.
• Material Science: Serves as a building block for creating organic semiconductors, light-emitting diodes (OLEDs), and other functional organic electronic materials.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and activity-based protein profiling (ABPP) reagents due to its reactive boronic ester group.
• Academic & Contract Research: A vital reagent for methodology development in organic synthesis and for constructing compound libraries for high-throughput screening.
• Catalyst Ligand Synthesis: Can be utilized to create novel, sophisticated ligands for transition metal catalysis.

Basic Information

Product Name	6-Bromo-1-(Toluene-4-Sulfonyl)-1H-Indole-3-Boronic Acid Pinacol Ester
CAS No.	1315354-68-7
Molecular Formula	C21H23BBrNO4S
Molecular Weight	476.19 g/mol
Synonyms	6-Bromo-1-tosyl-1H-indole-3-boronic acid pinacol ester; 1H-Indole-3-boronic acid, 6-bromo-1-[(4-methylphenyl)sulfonyl]-, 1,1-dimethylethyl ester; 6-Bromo-1-(p-toluenesulfonyl)-1H-indol-3-ylboronic acid pinacol ester; 6-Bromo-1-tosylindole-3-boronic acid pinacol ester; B-{6-Bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl}boronic acid pinacol ester; 6-Bromo-1-(4-methylbenzenesulfonyl)-1H-indole-3-boronic acid pinacol ester; 1315354-68-7
EINECS	Contact for details

Quality Control

Our 6-Bromo-1-(Toluene-4-Sulfonyl)-1H-Indole-3-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent chemical identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and reactivity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.