Description

3-Bromo-2-Chloropyridine-4-Boronic Acid Pinacol Ester is a high-value, multi-functional heterocyclic building block essential for modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in pharmaceutical and agrochemical research. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries to construct complex molecular architectures efficiently.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used to create novel pyridine-based herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science Research: Serves as a building block for constructing organic electronic materials, such as ligands for OLEDs and conductive polymers.
• Chemical Biology & Proteomics: Employed in the development of molecular probes and bioconjugation tools for target identification and validation.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura couplings to introduce the 3-bromo-2-chloro-4-pyridyl moiety into complex molecules.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis providers and CROs/CMOs developing proprietary compounds for clients.

Basic Information

Item	Details
Product Name	3-Bromo-2-Chloropyridine-4-Boronic Acid Pinacol Ester
CAS No.	1315351-37-1
Molecular Formula	C11H14BBrClNO2
Molecular Weight	318.40 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-bromo-2-chloropyridine; 2-Chloro-3-bromo-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 3-Bromo-2-chloro-4-pyridineboronic acid pinacol ester; 3-Bromo-2-chloropyridine-4-boronic acid pinacol ester; 2-Chloro-3-bromopyridine-4-boronic acid pinacol ester; (3-Bromo-2-chloropyridin-4-yl)boronic acid pinacol ester; B-(3-Bromo-2-chloro-4-pyridinyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 3-Bromo-2-Chloropyridine-4-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 11B), and GC/MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided for each lot. We adhere to cGMP guidelines where applicable to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.