Description

4-Amino-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzonitrile is a high-value, multifunctional boronic ester derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both an amino and a nitrile group adjacent to the boronate ester, makes it an indispensable reagent for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in Suzuki-Miyaura cross-coupling reactions and as a precursor for functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in creating biaryl structures common in kinase inhibitors and other therapeutic agents.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific, complex aromatic backbones.
• Material Science: Serves as a monomer or precursor in the development of organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Chemical Biology & Proteomics: Employed as a versatile handle for bioconjugation and the development of molecular probes and sensors due to its reactive functional groups.
• Academic & Contract Research: A valuable reagent for methodological development in organic synthesis and catalysis research within university and CRO laboratories.
• Ligand Synthesis: Used to prepare novel bidentate or tridentate ligands for transition metal catalysis.

Basic Information

Product Name	4-Amino-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzonitrile
CAS No.	1315350-04-9
Molecular Formula	C₁₃H₁₇BN₂O₂
Molecular Weight	244.10 g/mol
Synonyms	2-Amino-4-cyanophenylboronic acid pinacol ester; 3-Amino-4-cyanophenylboronic acid pinacol ester; 4-Cyano-2-aminophenylboronic acid pinacol ester; 4-Amino-3-(pinacolatoboryl)benzonitrile; Benzonitrile, 4-amino-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; (3-Amino-4-cyanophenyl)boronic acid pinacol ester; 1315350-04-9; 4-Amino-3-(pinacolboronato)benzonitrile
EINECS	Contact for details

Quality Control

Our 4-Amino-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and industry best practices for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.