Description

1-{[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methyl}Pyrazole is a high-purity, advanced pharmaceutical intermediate featuring a pyrazole moiety linked to a phenylboronic ester pinacol protecting group. This compound matters as a critical building block in modern organic synthesis, enabling efficient cross-coupling reactions for the construction of complex molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key arylboronic ester reagent for constructing biaryl and heterobiaryl structures in drug discovery.
• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) targeting various therapeutic areas.
• Agrochemical Synthesis: Employed as a building block for developing novel herbicides, fungicides, and insecticides.
• Material Science Research: Acts as a precursor for organic electronic materials, such as OLEDs and organic semiconductors.
• Chemical Biology Probes: Utilized in the development of molecular probes and inhibitors for biochemical research.
• Library Synthesis for High-Throughput Screening: Enables the rapid generation of diverse compound libraries for biological activity screening.

Basic Information

Product Name	1-{[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methyl}Pyrazole
CAS No.	1315281-50-5
Molecular Formula	C16H23BN2O2
Molecular Weight	286.18 g/mol
Synonyms	1-((4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)-1H-pyrazole; 1-[[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl]pyrazole; 1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)-1H-pyrazole; 4-(1H-Pyrazol-1-ylmethyl)phenylboronic acid pinacol ester; (4-(Pyrazol-1-ylmethyl)phenyl)boronic acid pinacol ester; 1-{[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}-1H-pyrazole
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Quality Control

Our 1-{[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methyl}Pyrazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.