Description

2-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl]-1,2,3,4-Tetrahydroisoquinoline is a high-purity, advanced pharmaceutical intermediate featuring a boronic ester pinacol group, a critical functional handle for modern cross-coupling reactions. This compound matters for its role in accelerating the synthesis of complex molecules, enabling more efficient and precise drug discovery pipelines. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel active ingredients and fine chemicals.

Application

• Suzuki-Miyaura Cross-Coupling Reagent: A key building block for creating carbon-carbon bonds in the synthesis of complex biaryl and heterobiaryl structures prevalent in modern pharmaceuticals.
• Pharmaceutical Intermediate: Used in the research and development of new drug candidates, particularly in oncology, CNS disorders, and antiviral therapies.
• Agrochemical Synthesis: Serves as a precursor in the development of novel herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLEDs and organic semiconductors, where precise molecular architecture is required.
• Chemical Biology Probes: Utilized to synthesize tagged molecules for studying biological pathways and protein interactions.
• Process Chemistry & Scale-Up: Provides a reliable and stable boronate source for optimizing and scaling manufacturing routes for target molecules.

Basic Information

Item	Details
Product Name	2-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl]-1,2,3,4-Tetrahydroisoquinoline
CAS No.	1315281-49-2
Molecular Formula	C22H28BNO2
Molecular Weight	349.28 g/mol
Synonyms	1,2,3,4-Tetrahydro-2-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl]isoquinoline; 2-(4-((1,2,3,4-Tetrahydroisoquinolin-2-yl)methyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (4-((1,2,3,4-Tetrahydroisoquinolin-2-yl)methyl)phenyl)boronic acid pinacol ester; B-(4-((1,2,3,4-Tetrahydroisoquinolin-2-yl)methyl)phenyl)boronic acid pinacol ester; THIQ-BPin derivative
EINECS	Contact for details

Quality Control

Every batch of our 2-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl]-1,2,3,4-Tetrahydroisoquinoline is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, NMR, and LC-MS to ensure identity, purity, and consistency meet the exacting standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.