Description

2-{4-[2-(4-Chlorophenyl)Ethynyl]Phenyl}-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane CAS NO 1315281-10-7 is a high-purity boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its value lies in enabling efficient cross-coupling reactions, specifically Suzuki-Miyaura couplings, which are fundamental for constructing complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing biphenyl or substituted aryl motifs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific chlorinated biaryl structures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs (Organic Light-Emitting Diodes) and semiconductors.
• Ligand and Catalyst Development: Employed in the synthesis of novel ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.
• Chemical Biology Probes: Useful in constructing molecular probes and tags for studying biological processes and target identification.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CROs (Contract Research Organizations) serving the global chemical industry.

Basic Information

Product Name	2-{4-[2-(4-Chlorophenyl)Ethynyl]Phenyl}-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1315281-10-7
Molecular Formula	C22H24BClO2
Molecular Weight	366.69 g/mol
Synonyms	4-(2-(4-Chlorophenyl)ethynyl)phenylboronic acid pinacol ester; (4-((4-Chlorophenyl)ethynyl)phenyl)boronic acid pinacol ester; 2-(4-((4-Chlorophenyl)ethynyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-Chlorophenylacetylene phenylboronic acid pinacol ester; PINACOL (4-((4-CHLOROPHENYL)ETHYNYL)PHENYL)BORONATE; B-[4-[(4-Chlorophenyl)ethynyl]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2-{4-[2-(4-Chlorophenyl)Ethynyl]Phenyl}-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation and to minimize moisture uptake. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥98.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.