Description

1-(5-Bromothiophen-3-Yl)-2,2,2-Trifluoroethanone is a high-value trifluoromethyl ketone derivative and a versatile building block in advanced organic synthesis. Its unique structure, featuring both a bromothiophene moiety and a reactive trifluoroacetyl group, makes it a critical intermediate for constructing complex molecules with tailored electronic and physical properties. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of molecules targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Research: Used in the discovery and synthesis of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Precursor: Serves as a building block for organic electronic materials, such as semiconductors for OLEDs and OFETs, due to the electron-withdrawing nature of the trifluoroacetyl group.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis and organocatalysts, enabling novel synthetic transformations.
• Fluorine Chemistry Research: An essential reagent for introducing the trifluoroacetyl functional group into heterocyclic systems, facilitating structure-activity relationship (SAR) studies.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	1-(5-Bromothiophen-3-Yl)-2,2,2-Trifluoroethanone
CAS No.	1314894-46-6
Molecular Formula	C6H2BrF3OS
Molecular Weight	258.04 g/mol
Synonyms	5-Bromo-3-trifluoroacetylthiophene; 3-Acetyl-5-bromothiophene, 3-trifluoro-; 1-(5-Bromo-3-thienyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(5-bromothiophen-3-yl)ethanone; 5-Bromo-3-(trifluoroacetyl)thiophene; 3-(Trifluoroacetyl)-5-bromothiophene; 1-(5-Bromo-thiophen-3-yl)-2,2,2-trifluoro-ethanone
EINECS	Contact for details

Quality Control

Our 1-(5-Bromothiophen-3-Yl)-2,2,2-Trifluoroethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development, ensuring reliability for your most demanding synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/GC-MS)	Conforms to reference standard
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (HPLC)	≥ 99.0% (High Purity Grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.