Description

4,4,5,5-Tetramethyl-2-(1-Phenylcyclopropyl)-1,3,2-Dioxaborolane is a high-value, advanced boronic ester building block essential for modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone methodology for constructing complex molecular architectures. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly in creating complex, sterically hindered biaryl structures common in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require specific, phenyl-substituted cyclic frameworks.
• Material Science & OLED Development: Serves as a precursor for creating organic electronic materials, including ligands for catalysts and emissive layers in organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura cross-coupling to introduce the 1-phenylcyclopropyl moiety into target molecules with high efficiency and selectivity.
• Academic & Industrial R&D: A vital reagent for methodological development in organic synthesis and for constructing compound libraries in high-throughput screening.
• Ligand & Catalyst Design: The boronic ester group can be utilized to create novel ligands for asymmetric catalysis or metal-organic frameworks (MOFs).

Basic Information

Product Name	4,4,5,5-Tetramethyl-2-(1-Phenylcyclopropyl)-1,3,2-Dioxaborolane
CAS No.	1314495-37-8
Molecular Formula	C₁₇H₂₅BO₂
Molecular Weight	272.19 g/mol
Synonyms	1-Phenylcyclopropane-1-boronic acid pinacol ester; (1-Phenylcyclopropyl)boronic acid pinacol ester; 1-Phenyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopropane; 2-(1-Phenylcyclopropyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1-Phenylcyclopropylboronic acid pinacol ester; B-(1-Phenylcyclopropyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 4,4,5,5-Tetramethyl-2-(1-Phenylcyclopropyl)-1,3,2-Dioxaborolane is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of cGMP for advanced intermediates and support compliance with global regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry, and well-ventilated place. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.