Description

2-Methyl-1H-Benzimidazole-5-Boronic Acid Pinacol Ester is a high-value boronic ester derivative, a crucial protected intermediate in modern synthetic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where it serves as a key building block for creating novel active ingredients and functional organic compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those containing the benzimidazole pharmacophore for antiviral, anticancer, or anti-inflammatory applications.
• Agrochemical Synthesis: Used in the research and development of new pesticides, herbicides, and fungicides, leveraging the Suzuki coupling to introduce complex substituents.
• Material Science Research: Serves as a monomer or precursor for creating organic electronic materials, such as OLEDs, conductive polymers, or metal-organic frameworks (MOFs).
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes, enzyme inhibitors, or bioconjugation reagents due to the reactivity of the boronic ester group.
• Academic & Process Chemistry: A valuable reagent for method development, catalysis studies, and scaling up synthetic routes in both academic and industrial R&D laboratories.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and fine chemical companies for use in client-specific, multi-step synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	2-Methyl-1H-Benzimidazole-5-Boronic Acid Pinacol Ester
CAS No.	1314216-34-6
Molecular Formula	C14H19BN2O2
Molecular Weight	258.13 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methyl-1H-benzimidazole; 2-Methyl-1H-benzimidazole-5-boronic acid pinacol ester; 2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazole; 2-Methyl-1H-benzo[d]imidazole-5-boronic acid pinacol ester; Benzimidazole-5-boronic acid pinacol ester, 2-methyl-; CAS 1314216-34-6
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for fine chemical intermediates. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry to confirm identity and purity. Certificates of Analysis (COA) detailing batch-specific results are available upon request. We adhere to a cGMP-compliant quality management system where applicable, ensuring traceability and consistency for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.