Description

1-Methyl-2-Oxopyridine-3-Boronic Acid, Pinacol Ester is a high-purity, protected boronic acid ester derivative, a crucial building block in modern synthetic chemistry. Its primary value lies in enabling efficient and selective cross-coupling reactions, such as the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery, process development, and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex heterocyclic scaffolds.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable, air- and moisture-tolerant boronate reagent for forming carbon-carbon bonds under mild conditions.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides requiring specific pyridone-based structures.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Material Science: A building block for creating organic electronic materials, polymers, and liquid crystals with tailored properties.
• Chemical Biology & Proteomics: Utilized in the synthesis of molecular probes and activity-based protein profiling (ABPP) reagents.

Basic Information

Product Name	1-Methyl-2-Oxopyridine-3-Boronic Acid, Pinacol Ester
CAS No.	1314140-36-7
Molecular Formula	C₁₂H₁₈BNO₃
Molecular Weight	235.09 g/mol
Synonyms	1-Methyl-2-oxo-1,2-dihydropyridine-3-boronic acid pinacol ester; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methylpyridin-2(1H)-one; 1-Methyl-2-oxo-1,2-dihydropyridine-3-boronic acid, pinacol cyclic ester; 1-Methyl-2(1H)-pyridinone-3-boronic acid pinacol ester; 3-Borono-1-methyl-2(1H)-pyridinone pinacol ester; 1-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2(1H)-one; N-Methyl-2-oxopyridine-3-boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 1-Methyl-2-Oxopyridine-3-Boronic Acid, Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with the standards required for research and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.