Description

1-Methylindazole-7-Boronic Acid Pinacol Ester is a high-purity, synthetically valuable organoboron building block. This compound is essential for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern pharmaceutical and agrochemical research. It is primarily utilized by R&D chemists and process development scientists in the life sciences sector for constructing complex molecular architectures, enabling the efficient synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing indazole-containing drug candidates in medicinal chemistry programs.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides requiring specific heterocyclic frameworks.
• Material Science Research: Serves as a precursor for creating functional organic molecules used in organic light-emitting diodes (OLEDs) and other electronic materials.
• Cross-Coupling Reactions: Specifically designed as a stable boronic ester for reliable, palladium-catalyzed Suzuki-Miyaura couplings with various aryl/heteroaryl halides.
• Chemical Biology Probes: Utilized in the synthesis of tagged molecules for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds at various scales, from milligram to kilogram.

Basic Information

Product Name	1-Methylindazole-7-Boronic Acid Pinacol Ester
CAS No.	1313738-64-5
Molecular Formula	C₁₄H₁₉BN₂O₂
Molecular Weight	258.13 g/mol
Synonyms	1-Methyl-1H-indazol-7-ylboronic acid pinacol ester; 7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methyl-1H-indazole; 1-Methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole; 1-Methyl-1H-indazole-7-boronic acid pinacol ester; 1-Methyl-7-boronic acid pinacol ester indazole; B-(1-Methyl-1H-indazol-7-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 1-Methylindazole-7-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing specifications such as assay (typically >95% by HPLC), NMR confirmation, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to handle the material under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to maintain stability and prevent hydrolysis. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.