Description

2-Phenylpyridine-3-Boronic Acid Pinacol Ester is a high-purity, organoboron building block essential for modern synthetic chemistry. This compound matters as a key reagent in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and advanced functional molecules.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides requiring specific biphenyl motifs.
• Materials Science Research: Employed in the creation of organic light-emitting diodes (OLEDs), liquid crystals, and conductive polymers where precise molecular architecture is crucial.
• Cross-Coupling Reactions: Serves as a versatile boronic ester partner in palladium-catalyzed Suzuki-Miyaura couplings to form carbon-carbon bonds under mild conditions.
• Chemical Library Development: Utilized in combinatorial chemistry and high-throughput screening for generating diverse compound libraries for drug discovery.
• Academic & Industrial R&D: A fundamental reagent for methodological development in organic synthesis and process chemistry optimization.

Basic Information

Product Name	2-Phenylpyridine-3-Boronic Acid Pinacol Ester
CAS No.	1313519-78-6
Molecular Formula	C₁₇H₂₀BNO₂
Molecular Weight	281.16 g/mol
Synonyms	2-Phenylpyridin-3-ylboronic acid pinacol ester; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-phenylpyridine; 2-Phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-Phenyl-3-pyridinylboronic acid pinacol ester; (2-Phenylpyridin-3-yl)boronic acid pinacol ester; Boronic acid, B-(2-phenyl-3-pyridinyl)-, 1,1-dimethylethyl ester; 1313519-78-6
EINECS	Contact for details

Quality Control

Our 2-Phenylpyridine-3-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (¹H and ¹³C), and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with full analytical data are provided for every shipment, supporting compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) for long-term storage to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.