Description

1-Bromo-3-(1,1-Difluoroethyl)-2-Fluorobenzene is a high-value, multi-halogenated aromatic building block of significant interest in advanced organic synthesis. Its molecular structure, featuring bromine, fluorine, and a difluoroethyl group, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, where its unique halogen pattern is leveraged to modulate bioactivity, metabolic stability, and physicochemical parameters.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, CNS-active compounds, and anti-infective agents.
• Agrochemical Synthesis: Employed in the design and synthesis of next-generation herbicides, fungicides, and insecticides, where the fluorine and bromine atoms contribute to enhanced lipophilicity and target binding.
• Material Science Precursor: Used in the development of specialty polymers, liquid crystals, and organic electronic materials due to its ability to influence molecular conformation and intermolecular interactions.
• Cross-Coupling Reactions: The bromine substituent acts as an excellent handle for versatile palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi, Stille) to form new carbon-carbon bonds.
• Fluorine Chemistry Building Block: The difluoroethyl and fluorine groups provide a source of fluorine for further chemical transformations, making it valuable for introducing fluorinated motifs into target molecules.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for exploring new synthetic methodologies and constructing complex, fluorinated molecular architectures.

Basic Information

Product Name	1-Bromo-3-(1,1-Difluoroethyl)-2-Fluorobenzene
CAS No.	1313426-10-6
Molecular Formula	C8H6BrF3
Molecular Weight	239.04 g/mol
Synonyms	2-Bromo-1-(1,1-difluoroethyl)-3-fluorobenzene; 3-Bromo-2-fluoro-α,α-difluoroethylbenzene; 1-Bromo-3-(1,1-difluoroethyl)-2-fluorobenzene; 2-Fluoro-3-bromo-α,α-difluoroethylbenzene; (1,1-Difluoroethyl)-2-fluoro-3-bromobenzene; 3-(1,1-Difluoroethyl)-2-fluoro-1-bromobenzene; Benzene, 1-bromo-3-(1,1-difluoroethyl)-2-fluoro-
EINECS	Contact for details

Quality Control

Our production of 1-Bromo-3-(1,1-Difluoroethyl)-2-Fluorobenzene adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization using techniques including GC, HPLC, NMR, and MS to confirm identity and purity. Certificates of Analysis (COA) detailing all relevant specifications are provided with every shipment. We support cGMP compliance for advanced intermediates and can tailor quality documentation to meet specific customer and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider maintaining the material under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.