Description

6-(4-Hydroxypiperidin-1-Yl)Pyridine-2-Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and building block featuring a protected boronic acid group. This compound is critically important for facilitating efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry and materials science. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of complex molecules and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly for kinase inhibitors and other small molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between aryl/heteroaryl halides and boronic acids, essential for constructing complex biaryl and heterobiaryl scaffolds.
• Medicinal Chemistry Research: Used in high-throughput screening libraries and structure-activity relationship (SAR) studies to explore new chemical space and optimize lead compounds.
• Agrochemical Synthesis: Serves as a precursor in the development of novel herbicides, fungicides, and insecticides requiring specific heterocyclic architectures.
• Material Science: Potential use in the synthesis of organic electronic materials, such as polymers and small molecules for OLEDs or organic photovoltaics.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up services for the life sciences sector.

Basic Information

Product Name	6-(4-Hydroxypiperidin-1-Yl)Pyridine-2-Boronic Acid Pinacol Ester
CAS No.	1313040-65-1
Molecular Formula	C16H25BN2O3
Molecular Weight	304.19 g/mol
Synonyms	6-(4-Hydroxypiperidin-1-yl)pyridine-2-boronic acid pinacol ester; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(4-hydroxypiperidin-1-yl)pyridine; 1-[6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperidin-4-ol; 6-(4-Hydroxy-1-piperidinyl)-2-pyridineboronic acid pinacol ester; Pinacol 6-(4-hydroxypiperidin-1-yl)pyridine-2-boronate; Boronic acid, B-[6-(4-hydroxy-1-piperidinyl)-2-pyridinyl]-, pinacol ester; CAS 1313040-65-1
EINECS	Contact for details

Quality Control

Our 6-(4-Hydroxypiperidin-1-Yl)Pyridine-2-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment and are available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.