Description

4-Fluoro-Pyrrolidine-2-Carboxylic Acid Methyl Ester is a high-value fluorinated pyrrolidine derivative, a crucial chiral building block in modern synthetic chemistry. Its core value lies in providing a structurally defined, functionalized scaffold for constructing complex molecules with enhanced biological activity and metabolic stability. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, process development, and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to introduce fluorine atoms for modulating potency, selectivity, and ADMET properties.
• Peptidomimetic Synthesis: Serves as a constrained proline analog for creating novel peptide-like compounds with improved stability against enzymatic degradation.
• Agrochemical Active Ingredient Development: Employed in the synthesis of advanced herbicides, fungicides, and insecticides requiring fluorinated heterocycles.
• Ligand and Catalyst Preparation: Useful for constructing chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Acts as a building block for fluorescent tags or activity-based probes to study enzyme function.

Basic Information

Product Name	4-Fluoro-Pyrrolidine-2-Carboxylic Acid Methyl Ester
CAS No.	1313017-51-4
Molecular Formula	C6H10FNO2
Molecular Weight	147.15 g/mol
Synonyms	Methyl 4-fluoropyrrolidine-2-carboxylate; 4-Fluoro-DL-proline methyl ester; (4R/S)-Fluoropyrrolidine-2-carboxylic acid methyl ester; Methyl (4-fluoropyrrolidin-2-yl)carboxylate; 4-Fluoro-2-pyrrolidinecarboxylic acid methyl ester; 4-Fluoropyrrolidine-2-carboxylic acid, methyl ester; 4-Fluoro-L-proline methyl ester (racemic mixture); 4-Fluoroproline methyl ester
EINECS	Contact for details

Quality Control

Our 4-Fluoro-Pyrrolidine-2-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity and impurity profiling, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.