Description

3-[[3,5-Bis(Trifluoromethyl)Phenyl]Amino]-4-[[(1S,2S)-2-(1-Piperidinyl)Cyclohexyl]Amino]-3-Cyclobutene-1,2-Dione is a sophisticated, high-value organic intermediate featuring a cyclobutenedione core with chiral amine substituents. This compound matters for its role as a key building block in the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate its unique stereochemistry and trifluoromethylated aromatic system into novel active compounds.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders or requiring chiral specificity.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the trifluoromethyl groups can enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: The chiral diamine structure makes it a candidate for developing asymmetric catalysts or metal-chelating ligands for organic transformations.
• Advanced Material Synthesis: Potential building block for functional polymers or organic electronic materials due to its conjugated system and robust aromatic components.
• Chemical Biology Probes: Utilized in the design of molecular probes for studying enzyme function or protein-protein interactions within biological systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthetic routes requiring this specialized intermediate.

Basic Information

Product Name	3-[[3,5-Bis(Trifluoromethyl)Phenyl]Amino]-4-[[(1S,2S)-2-(1-Piperidinyl)Cyclohexyl]Amino]-3-Cyclobutene-1,2-Dione
CAS No.	1312991-15-3
Molecular Formula	C25H25F6N3O2
Molecular Weight	513.48 g/mol
Synonyms	(1S,2S)-N1-(3,5-Bis(trifluoromethyl)phenyl)-N2-(2-(piperidin-1-yl)cyclohexyl)cyclobut-3-ene-1,2-dione-1,2-diimine; 3-((3,5-Bis(trifluoromethyl)phenyl)amino)-4-(((1S,2S)-2-(piperidin-1-yl)cyclohexyl)amino)cyclobut-3-ene-1,2-dione; CAS 1312991-15-3; Chiral Cyclobutenedione Diamine Derivative; Bis(trifluoromethyl)aniline Cyclobutenedione Adduct; (S,S)-Cyclobutenedione Diamine Intermediate
EINECS	Contact for details

Quality Control

Our production of 3-[[3,5-Bis(Trifluoromethyl)Phenyl]Amino]-4-[[(1S,2S)-2-(1-Piperidinyl)Cyclohexyl]Amino]-3-Cyclobutene-1,2-Dione adheres to stringent quality protocols suitable for GMP-like environments for non-pharmaceutical use. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure identity, potency, and consistency. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound may be hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.