Description

1-Boc-Pyrrolidine-3-Boronic Acid Pinacol Ester is a high-purity, protected boronic acid ester building block essential for modern synthetic chemistry. This compound is a critical intermediate in the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing novel chemical entities via cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those containing pyrrolidine scaffolds.
• Suzuki-Miyaura Cross-Coupling: Enables the formation of carbon-carbon bonds with aryl or vinyl halides, a cornerstone reaction in medicinal chemistry and material science.
• Medicinal Chemistry & Drug Discovery: Used in high-throughput screening libraries and for the structure-activity relationship (SAR) optimization of lead compounds.
• Peptidomimetic Synthesis: Facilitates the incorporation of modified pyrrolidine units into peptide backbones to enhance stability and bioavailability.
• Agrochemical Research: Serves as an intermediate in the development of novel herbicides, fungicides, and insecticides.
• Ligand and Catalyst Development: Used in the preparation of novel chiral ligands and organometallic catalysts for asymmetric synthesis.

Basic Information

Product Name	1-Boc-Pyrrolidine-3-Boronic Acid Pinacol Ester
CAS No.	1312712-22-3
Molecular Formula	C15H28BNO4
Molecular Weight	297.20 g/mol
Synonyms	tert-Butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolidine; 3-Borono-1-Boc-pyrrolidine pinacol ester; 1-Boc-3-boronopyrrolidine pinacol ester; N-Boc-3-pyrrolidineboronic acid pinacol ester; 1-Boc-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolidine
EINECS	Contact for details

Quality Control

Our 1-Boc-Pyrrolidine-3-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for research and development applications. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry. Certificates of Analysis (COA) are available for every batch upon request, detailing all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep container tightly sealed in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.